Preparation of biocompatable film using chitosan and hydroxyapatite

摘要

PURPOSE: A method for making a biocompatible film using chitosan and hydroxyapatite is provided to obtain a biocompatible film having excellent transparency, physical properties, biocompatibility and anti-bacterial property. CONSTITUTION: The method for making a biocompatible film comprises the steps of: (a) forming a chitosan complex that contains nanoparticles of hydroxyapatite; (b) adding a polycarboxylic acid to the complex obtained from the step (a); and molding hydroxyapatite nanoparticles-containing chitosan film from the mixture obtained from the step (b). If desired, the method further comprises the step of treating the film obtained from the step (c) with an acetic anhydride-containing lower alcohol to provide a hydroxyapatite nanoparticles-containing chitin film.