首页>
外国专利>
Apicidin-derivatives, their synthetic methods, and antitumor compositions containing the same
Apicidin-derivatives, their synthetic methods, and antitumor compositions containing the same
展开▼
机译:芹菜素衍生物,其合成方法以及含有它们的抗肿瘤组合物
展开▼
页面导航
摘要
著录项
相似文献
摘要
A substituted apicidin derivative, a method of synthesis therefore, and an anti-tumor composition comprising the same are disclosed. The substituent of the derivative is preferably semicarbazone, thiosemicarbazone, hydrazone, tert-butylhydrazone, phenylhydrazone, 2,4-dinitrophenylhydrazone, 4-methoxyphenylhydrazone, 3-methoxyphenylhydrazone, 4-nitrophenylhydrazone, benzylhydrazone, methanesulfonylhydrazone, benzenesulfonylhydrazone, 4-methylbenzenesulfonylhydrazone, benzoylhydrazone, 4-nitrobenzoylhydrazone, carbohydrazone, benzyloxime or acetoxime. The compound has strong inhibition effect against histone deacetylase and detransforming activities and specifically inhibit growth of cancer cells. Therefore, it is useful in preparation of an anti-tumor composition.
展开▼