A method for finding of ligands which bind to a drug target, by means of nmr - displacement experiments.

摘要

The present invention relates to a method for identifying and screening of active substances which bind to a drug target, which, on the basis of the process of the heteronuclear nmr - spectroscopy is based. It is more particularly based on the principle of the competitive displacement, whereby the displacement of isotope-labeled relatively weakly be bound by the sought scout - ligands, ligands a higher affinity is observed. In a further embodiment, the method according to the invention for admetox - optimization of known active agents. In this case it is important, from known active compounds or derivatives thereof to identify those representatives which, as far as possible, poorly to bind a test enzyme.