nucleotide and peptidsequenzen of immunodeficiency virus isolate of the cat, and applications where the sequences in the diagnosis and prevention of infection

摘要

Nucleotide sequences derived from the feline immunodeficiency virus (strain Wo of the FIV virus), application of the said sequences especially for the expression of immunogenic and/or neutralising peptides, plasmides useful for the said expression and process for the detection, differentiation and identification of FIV strains by means of at least one of the said nucleotide sequences. Peptides and their fragments encoded by a nucleotide sequence or a combination of several nucleotide segments such as defined above, which are specific for the feline immunodeficiency virus (FIV) and use of the said fragments as diagnostic reagent and as a agent inducing an immune response (cellular and/or production of antibodies), especially for the prevention of feline immunodeficiency. The peptides and/or peptide fragments are recognised by antibodies directed against at least one strain different from that from which the said peptide is obtained and/or by the antibodies produced by naturally infected cats, and they exhibit a capacity to induce a cellular immune response and/or to produce antibodies which protect against at least one FIV strain, in non-infected cats.