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PHARMACEUTICAL TABLET WITH DELAYED RELEASE, CONTAINING A MATRIX OF CROSS-CROSSLINKED AMYLOSE AND HYDROXYPROPYL METHYL CELLULOSE
PHARMACEUTICAL TABLET WITH DELAYED RELEASE, CONTAINING A MATRIX OF CROSS-CROSSLINKED AMYLOSE AND HYDROXYPROPYL METHYL CELLULOSE
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机译:延迟释放的药物片剂,包含交联淀粉和羟丙基甲基纤维素的基质
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摘要
Disclosed is a pharmaceutical controlled release tablet containing an active ingredient in combination with a carrier made of cross-linked amylose in which hydroxymethylpropylcellulose (HPMC) with a viscosity higher than or equal to 4000 cps is added as an adjuvant. The addition of HPMC to the tablet permits to control the effect of enzymes, and more particular alpha-amylase present in the intestinal medium, on the cross-linked amylose used as a carrier, and thus to reduce the dependence of the kinetics of release upon the concentration of enzymes present in the medium.
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