Molecules of a photosensitising agent and of an agent chemotherapeutic, their process of production and their application in photodynamic chemotherapy and

摘要

a) The preparation of hybrid molecules of formulae (2) and (3), by reaction of a Zn(II), Sn(IV) or Al(III) derivative of a porphyrin or phthalocyanin with taxol or baccatine III, in the presence of an anhydrous polar solvent at 0 - 120 deg C, is new. One of R1 and R2 = H and the other = -CO-O-P, -OCH2-CO-O-P, or -(CH2)2-CO-O-P R3 = -CO-O-P, -OCH2-CO-O-P, or -(CH2)2-CO-O-P, P = a metal derivative of a porphyrin (a) or of a phthalocyanin (b) X = phenyl, methylphenyl, chlorophenyl, or naphthyl, M = Zn(II), Sn(IV) or Al(III). b) Compounds of formulae (2) in which R1 = CO-P or CO-CH2-O-P, P = a porphyrin group in which the metal is not present and X = methyl phenyl, compounds of formula (2) in which R2 = -CO-CH2-O-P, P = a porphyrin group in which the metal is not present and X = methyl phenyl, and compounds of formula (3) in which R3 = -CO-CH2-O-P, P = a porphyrin group in which the metal is not present and X = methyl phenyl, are claimed per se.