BRAND PEPTIDES HAVING AFFINITY FOR PHOSPHOLIPID AND USES

摘要

The present invention relates to a peptide labeled with Fluor-18 for the specific recognition of lipid vectors. The peptide of the invention comprises the following peptide sequence (PI): J1-J2-J3-J4-J5-J6-Z7-U8-J9-J10-U11-Arg-J13-J14-U15-Lys-Gly-X18 -Gly-Thr-J21-Glu-J23-J24-U25-J26-J27-J28-U29-J30-J31-Arg-J33-J34-J-35-J36-B37-J38-J39-U40-J41-J42 -J43-U44-J45-J46-J47-J48-J49-Arg-J51-U52-J53-J54-Asp-U56-Lys-Ser-Z59-Leu-J61-J62-J63-J64-Z65-J66-J67 -U68-J69-J70-J71-U72-J73-J74-J75 (PI) in which the amino acids J are chosen independently from each other from essential amino acids, or derivatives thereof, in such a way that at least 50% of them are polar residues chosen from Arg, Asn, Asp, Cys, Gln, Glu, Gly, His, Lys, Orn, Pro, Ser, Thr and Tyr; the amino acids U are chosen independently from each other from Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val; amino acid X18 is chosen independently of the other amino acids of the sequence from Ala, Asn, Cys, Gln, Gly, His, Ile, Leu, Met, Phe, Ser, Thr, Trp, Tyr and Val; amino acid B37 is chosen independently of the other amino acids of the sequence from Arg, Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val; the amino acid Z7 is chosen independently of the other amino acids from Asp or Glu; amino acids Z59 and Z65 are chosen from Glu, Asp, Lys or Arg; the exponents of residues J, Z, U, X and B representing the position of these amino acids in said sequence.