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Atorvastatin hemi-calcium essentially free of organic solvent and desolvation method of atorvastatin hemi-calcium solvates
Atorvastatin hemi-calcium essentially free of organic solvent and desolvation method of atorvastatin hemi-calcium solvates
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机译:阿托伐他汀半钙基本不含有机溶剂和阿托伐他汀半钙溶剂化物的去溶剂化方法
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摘要
The present invention provides processes for removing organic solvent from crystals of atorvastatin hemi-calcium containing organic solvent. In one process, the organic solvent is displaced by vapor diffusion of water in a vessel maintained at elevated humidity. In a second process, the organic solvent is removed by fluidized bed drying. The present invention further provides atorvastatin hemi-calcium containing 1% or less organic solvent, which can be obtained from atorvastatin hemi-calcium that has been crystallized from an organic solvent-containing solution by practice of the processes of the invention.
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