METHOD FOR DESOLVATION OF ATORVASTATIN HEMI-CALCIUM SOLVATE AND ATORVASTATIN HEMI-CALCIUM ESSENTIALLY FREE OF ORGANIC SOLVENT

摘要

PPROBLEM TO BE SOLVED: To provide a method for removing organic solvent from atorvastatin hemi-calcium crystals including organic solvent. PSOLUTION: In one method, the organic solvent is substituted by water-vapor diffusion in a vessel kept in high humidity. In a second method, an organic solvent is removed by fluidized bed drying. This invention further provides atorvastatin hemi-calcium including only less than 1% of organic solvent, and it can be obtained from the atorvastatin hemi-calcium crystallized from that solution formed by carrying out the method of this invention. PCOPYRIGHT: (C)2009,JPO&INPIT