Non human pregnane X receptor arrangement in order to use for relative pharmacology

摘要

The dog and the Primates, the cover and the pregnane X receptor of the fish (PXR) the manifestation vector and the host cell for revelation of the polynucleotide and the polypeptide, and these PXR receptors are offered. In addition, the screening are done because of method, and the relative pharmacology which, also the method of using these receptors and, at the time of selecting the clinical model animal before the appropriateness which can estimate human PXR activity, is offered mojiyureta of these PXR receptors.