Nucleic acid encoding the same polypeptide and N- acetylgalactosamine transferase: new UDP-N- acetyl galactosamine -D-

摘要

By isolating the enzyme having an activity to transfer a α1 bind N- acetylgalactosamine serine of the peptide sequence and the core protein, the hydroxyl group of threonine residues, and to clarify the structure of the gene, genetic engineering of the enzyme arsenide identification production Na, production as a substrate, such as GalNAc modified proteins or GalNAc modified peptide based on the enzyme, was added unknown O- linked sugar chain based on the enzyme unknown protein or peptide of O--linked sugar chain modification position and, and allowing the diagnosis of a disease based on the gene and the like. More amino acids may be deleted or substituted with one or at the amino sequence or amino acid sequence shown in SEQ ID NO: 1-7 of the Sequence Listing, or a plurality of amino acids have been added or are inserted into one or the amino sequence The use of nucleic acids encoding the proteins and protein having the activity of transferring a α1 binding N- acetylgalactosamine and (GalNAc) serine of the peptide core or protein having an amino acid sequence, serving as a substrate, the hydroxyl group of the threonine residues.