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Dna separation using linear polymer solutions with dimethyl sulfoxide
Dna separation using linear polymer solutions with dimethyl sulfoxide
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机译:使用线性聚合物溶液与二甲亚砜进行Dna分离
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摘要
The invention is directed to a high throughput nucleic acid separation method using an improved uncrosslinked polymer separation matrix for increasing read length and separation speed, while maintaining accuracy, for, e.g., nucleic acid sequencing. The separation matrix of the invention includes a denaturant comprising dimethyl sulfoxide (DMSO). Preferably, the separation matrix may further comprise urea. Preferred matrix polymers include linear polyacrylamide, poly(ethylene oxide), hydroxyethyl cellulose, poly(dimethylacrylamide) and poly(vinylpyrrolidone).
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