Transgenic plant-based vaccines

摘要

A DNA construct that encodes, when expressed in a plant cell, a protein complex comprising five monomeric fusion proteins; where each fusion protein comprises a cholera toxin B subunit linked at the 3′ end of the cholera toxin B subunit to a first immunogenic antigen from a causal factor of a first infectious mammalian disease other than cholera; and where the antigen elicits a protective response to the disease.