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Analgetic dosage forms that are resistant to parenteral and inhalation dosing and have reduced side effects
Analgetic dosage forms that are resistant to parenteral and inhalation dosing and have reduced side effects
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机译:对肠胃外和吸入剂量有抵抗力且副作用减少的镇痛剂型
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摘要
The invention provides a novel solid pharmaceutical dosage form which includes an opiate, an opiate antagonist admixed with the analgetic (opiate agonist) and an amount of a hydrocolloid containing excipient which is effective to form a non-injectable slurry when the dosage form is contacted with water. In addition the dosage form contains pure naloxone in enteric coated form which is designed to release in the colon to prevent or relieve constipation. Thus the formulation, because of the enteric coated naloxone and the hydrocolloid excipient(s), has reduced side effects as compared with formulations which do not contain these features.
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