Effects of Low Dose of Ketotifen and Chloroquine Combination on the Ultras tructure of Chloroquine Resistant Strain of Plasmodium Yoelii

摘要

1　Ｉｎｔｒｏｄｕｃｔｉｏｎ　Ｔｈｅｗｉｄｅｓｐｒｅａｄｄｅｖｅｌｏｐｍｅｎｔｏｆｃｈｌｏｒｏｑｕｉｎｅｒｅｓｉｓ ｔａｎｔ (ＣＲ)ｓｔｒａｉｎｏｆｍａｌａｒｉａｈａｓｒｅｓｕｌｔｅｄｉｎｓｅａｒｃｈｉｎｇｆｏｒｎｅｗｅｆｆｅｃｔｉｖｅａｎｔｉ ｍａｌａｒｉａｄｒｕｇｓ[1～ 4 ] .Ａｎａｎｔｉ ａｓｔｈｍａａｎｄａｎｔｉ ｍａｌａｒｉａｄｒｕｇｋｅｔｏｔｉｆｅｎ (Ｋ)ｈａｓｂｅｅｎｐｒｏｖｅｄｔｏｓｈｏｗｓｔｒｏｎｇａｎｔｉ ｍａｌａｒｉａａｃｔｉｏｎｂｙＰａｎｅｔａｌ[5～ 7] .ＦｕｒｔｈｅｒｍｏｒｅＫｈａｄｓｔｒｏｎｇｅｒｒｅｖｅｒｓｅｅｆｆｅｃｔｏｎＰ .ｙｏｅｌｉｉ (ＣＲ)ｔｈａｎＶｅｒａｐｍｉｌ[8] .ＴｈｅｕｌｔｒａｓｔｒｕｃｔｕｒｅｓｔｕｄｙｈａｓｒｅｖｅａｌｅｄｔｈａｔｔｈｅｅｆｆｅｃｔｏｆＫ ( 10ｍｇ·ｋｇ- 1·ｄ- 1)ｏｎｃｈｌｏｒｏｑｕｉｎｅ ｓｅｎｓｉｔｉｖｅ(ＣＳ)ｓｔｒａｉｎｏｆＰ .ｙｏｅｌｉｉａｎｄＫ ( 4 0ｍｇ/ｋｇ·ｄ)ｏｎＰ .ｙｏｅｌｉｉ (ＣＲ)ｉｓｄｉｆｆｅｒｅｎｔｆｒｏｍｏｔｈｅｒａｎｔｉ ｍａｌａｒｉａｄｒｕｇｓｗｉｔｈｔｈｅｃｈａ...