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Dual inhibition of cyclooxygenase-2 and carbonic anhydrase
Dual inhibition of cyclooxygenase-2 and carbonic anhydrase
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机译:双重抑制环氧合酶2和碳酸酐酶
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摘要
Compounds of Formula I potently inhibit both cyclooxygenase-2 and carbonic anhydrases. Inhibition of carbonic anhydrases by a cyclooxygenase-2 inhibitor may affect significantly the safety and efficacy profiles of such a dual inhibitor in the treatment of cyclooxygenase-2 mediated disorders, compared to a cyclooxygenase-2 inhibitor without carbonic anhydrase inhibitory activity.
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