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Assay for detecting changes in mitochondrial membrane permeability and method of using same
Assay for detecting changes in mitochondrial membrane permeability and method of using same
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机译:检测线粒体膜通透性变化的测定方法及其使用方法
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摘要
An assay for assessing the permeability of mitochondrial membranes is provided. The assay is based on enzymatic reactions that produce a detectable signal in the presence of intra-mitochondrial compounds. In some embodiments, the intra-mitochondrial compounds may be reduced and/or oxidized nicotinamide adenine dinucleotides (i.e., NADH and NAD+, respectively). The assay may optionally be provided in the form of a kit, and may further be useful in the discovery and interrogation of compounds that may serve to inhibit pathologic increase in mitochondrial membrane permeability, which is associated with numerous and varied mammalian disease.
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