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Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
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机译:具有位点特异性手性硫代磷酸酯核苷间键的缺口低聚物
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摘要
Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5′, and the 3′-terminal internucleoside linkages are chirally Sp and internal internucleoside linkages are chirally Rp.
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