Adenosine A2A Receptor Antagonists of amino - 5 - 1,2,4 - triazole bicyclic, Pharmaceutical compositions containing the same, alone or in combination of the compounds and other agents for Preparation of Drugs useful in the treatment of Parkinson's disease and a

摘要

1. A 5-amino-1, 2, 4-tricyclic compound represented by structural formula (1) or salt acceptable to the drug, wherein a is C (R1) or N; R1 and R1a are independently selected from group h-asphalt (C1-6),Halo, CN and CF3, this is - O,- yes.-So...-SO2...R5 isopropyl glycol, R5 arileno or some other formula (2);P and Q are independent 2-3; Q and Q1 are selected independently from the following groups: n, CH, CCN, COH and CC (o) CH3, provided that at least one Q and Q1 is n; R is R5 arilo, R5 direct arilo, R6 alquelino (c2-6) or R6 asphalt (c2-6);R2 is R5 arilo, R5 heterogeneous, R5 aril asphalt (C1-6) or R5 heterogeneous asphalt (C1-6);O r2-y as shown in the structure (3);U. V, and W are selected independently from group n and CR1, provided that at least one u, V and W is CR1; n is 1, 2 or 3; and (a) a is C (R1) and X is C (R3) (R3a).-C (O) -- that is...- yes.-So...-SO2...R4 arileno, R4 tremolite, o-n (R9) -,Or C (R1),This is a link, and X is - C (R3) (R3a)-C (O) -- that is...- yes.-So...-SO2...R4-arileno -N (R9) -e. Or R4 - tremolite, if x sea-n (R9) - or R4 - tremolite, R2 - non phenyl or phenyl - hydrocarbon (C1-6);Or (b) a is n, X is - n (R9) -,This is R5 arileno and R2 is a residual formula (4) or n is 2 or 3; and (c) a is n and X is - C (R3) (R3a).-C (O) -- that is...- yes.-So...-SO2...-N (R9) -R4 arileno or R4 tremolite; or a is n, is a link and X is - C (o) -,-N (R9) -R4 arileno R4 tremolite; or a is n, and a is n (r9a),-C (o) n (r9a) - O-O (CH2) 2-N (r9a) - and xes-n (R9) -;O a is n, X is n (R9) - E and R2, as a whole, structure (4) and N are 0; Y (d) is n, is a link, X is n (R9), R2 is selected from formula group (5);O (E) a is n, X is - n (R9) - E and R2 are added together, as shown in formula (6);Where Z is - C (o) - CH2,-C (o) - CH (C1-6 tar) -,-CH2CH (C1-6 tar) -,1. O-ch (C1-6 tar) - CH2 -;R3 and R3a are independently selected from the group consisting of H, -OH, C1-6 alkyl, hydroxy-C1-6 alkyl,2. Alcoxi (C1-6) - tar (C1-6),Carbamate (C1-6),1. Lease (C1-6) - Asphalt (C1-6) and diaklamine (C1-6) - Asphalt (C1-6);R4 is a 1-3 alternative selected from class H asphalt (C1-6),-Oh, alcoxi (C1-6),alcoxi (C1-6) -alcoxi (C1-6)Halo -, CF3 and CN; R5 are 1-3 alternatives selected from class H asphalt (C1-6),-Oh, alcoxi (C1-6),2. Alcoxi (C1-6) - tar (c1-9);alcoxi (C1-6) -alcoxi (C1-6)Halo, CF3, CN, NH2, rental (C1-6),dialquilamino (C1-6)1. Amino tar (C1-6),1. Lease (C1-6) - Bitumen (C1-6),1. Cumin (C1-6) - tar (C1-6),Alkane (C1-6) - ammonia, amine sulfite (C1-6),Bitumen (C1-6),Bitumen (C1-6) - Bitumen (C1-6),R6-alquenilo (C2-6)R6 asphalt (c2-6),Hydroxy asphalt (C1-6),2. Alcox (C1-6) - C (o) - amine, or isopropyl tar (C1-6);R6 is one to three alternatives selected from class H asphalt (C1-6),Oh, alcoxi (C1-6) and halo; R7 and r7a are independently selected from class H asphalt (C1-6),2. Alcoxi (C1-6) - tar (C1-6),R8 arilo and R8 heterosexual, or R7 and r7a substitutes in the same carbon can form = O; R8 is a 1-3 substitute independently selected from h, hydrocarbon (C1-6),-Oh, alcoxi (C1-6),alcoxi (C1-6) -alcoxi (C1-6)Halo -, CF3 and CN; R9 and r9a were selected independently from the h-tar (C1-6) group,Hydroalkyl (c2-6),2. Alcoxi (C1-6) - Asphalt (c2-6),1. Amino asphalt (c2-6),1. Rental (C1-6) - Asphalt (c2-6),1. Cumin (C1-6) - tar (c2-6),halo-alquelino (C3-6)CF3 tar (C1-6),alquenilo (C3-6)Bicycle (C3-6),e. Cyclopentanediol (C3-6) - Asphalt (C1-6);R10 is H-C (o) - o-asphalt (C1-6),R5 arilo, C (o) - Bitumen (C1-6),-C (o) - (R5 arilo) or R5 aril acquilo (C1-6). Drugs used to treat Parkinson's disease, used alone or in combination with other drugs to treat Parkinson's disease, drug synthesis to understand Parkinson's disease, and toolkits including composite components.