Compounds derived from 5 - amino pyrazole e - 4.3 - 1,2,4-triazole - 1.5 - c - pyrimidineAdenosine A2A receptor antagonist; Intermediates; procedure of preparation of compounds, Pharmaceutical Composition and Use thereof for treating the disease depresiion, CognitiveStroke and Neurodegenerative Diseases, such as Parkinson's disease.

摘要

Compounds having the Structural formula I or a pharmaceutically acceptable of the same, in which R is phenyl substituted opcinalmente, cicloalquenilo,Or herteroarilo; X is alquileno or - CH2 - C (o); and - N (R2) (ch2ch2n (R3), och2ch2 (R2) - S, - - - - - (CH2 ch2s (2, - NH -, or optionally substituted M and N are 2 - 3And Q is nitrogen or carbon optionally substituted phenyl; and Z is optionally substituted phenyl or heteroaryl fenialquilo difenilmetilo, R6, - C (o) - R6 - SOS,R6 R7 OC - (OR) - N - (R8) - C (o) - N - (R7, R8) - C (S) - phenyl - ch (OH) -, - C (= nor2 or phenyl) -; or when q is CHPhenylamino or piridilamino; or Z and are jointly and piperidinilo replaced or substituted phenyl; and R2, R3, R4, R7 and R8 are as defined in the memory,And its use for the treatment of Parkinson's disease, alone or in combination with other agents for treating Parkinson's diseaseAnd the pharmaceutical compositions containing, and also relates to a method for preparing Intermediate useful in preparing the compound of formula I.