Dosage forms and compositions for Administration of varying dosages of oxycodone Osmotic

摘要

Claim 1: a controlled release dosage form for oral administration once a day of oxycodone that includes: (a) a Center of Drug comprising: (i) an Osmotic agent; and (ii) a low dose of oxycodone.Or one or more pharmaceutically acceptable salts thereof; (b) a semipermeable Membrane that surrounds at least part of the centre of drugs; and (c) an outlet Orifice through the semipermeable Membrane that communicates with the center of the drug in order to allow the release of Ox Icodone environment; where the center of the Drug After the moisture in the atmosphere exhibits aViscosity of about 50 to 100 cps CPS.Claim 8: a controlled release dosage form for oral administration once a day of oxycodone that includes: (a) a Center of Drug comprising: (i) a high dose of oxycodone, or one or more pharmaceutically acceptable salts thereof; and (ii) does not contain And an Osmotic agent; (b) a semipermeable Membrane that surrounds at least part of the centre of Drugs,And (c) an outlet Orifice through the semipermeable Membrane that communicates with the center of the drug to allow the release of oxycodone to environment; where the center of the Drug After the moisture in the atmosphere exhibits a viscosity of about 50 cps to from sal Between 100 cps.Claim 12: a controlled release dosage form for oral administration once a day of oxycodone that includes: (a) a Center of Drug comprising: (i) an Osmotic agent; and (ii) a low dose of oxycodone.Or one or more pharmaceutically acceptable salts thereof; (b) a semipermeable Membrane that surrounds at least part of the centre of drugs; and (c) an outlet Orifice through the semipermeable Membrane that communicates with the center of the drug in order to allow the release of Ox Icodone environment; where the rate of release is approximately 20% to 100%.Claim 13: a controlled release dosage form for oral administration once a day of oxycodone that includes: (a) a Center of Drug comprising: (i) a high dose of oxycodone.Or one or more pharmaceutically acceptable salts thereof; and (ii) does not contain an Osmotic agent; (b) a semipermeable Membrane that surrounds at least part of the centre of drugs; and (c) an outlet Orifice through the semipermeable Membrane that communicates with the Centre for Drugs Allow the release of oxycodone to environment; where the rate of release is approx.And 20% to 100%.