Controlled release dosage forms and compositions for osmotic delivery of variable dosages of oxycodone

摘要

Disclosed is a controlled release oral dosage form for once-a-day administration of oxycodone comprising: (a) a drug core which comprises: (i) an osmotic agent; and (ii) a low dose of oxycodone, or one or more pharmaceutically-acceptable salts thereof; (b) a semipermeable membrane at least partially surrounding the drug core; (c) an exit orifice through the semipermeable membrane which communicates with the drug core so as to allow release of the oxycodone to the environment; and (d) an expandable layer which does not comprise oxycodone; wherein the drug core upon hydration in the environment exhibits a viscosity of about 50 cps to 100 cps.