Deriados of acilaminotiazol, their Preparation and their application in Therapeutics

摘要

The compounds conform to the general formula (1): R1 represents a C1-6 tar (eventually substituted), a c3-7 cyclopentyl, a sulfur phosphorus, a benzo sulfur phosphorus, a pyridine, a furan or a phenyl; the phenyl group will eventually be substituted; R2 and r.2 represent them respectively,N. Halogen atom, hydroxyl atom, c1-3 alkoxy, c1-3 hydrocarbon, c1-3 epoxy compound, c3-7 epoxy compound, O-C (or) - C1-6 or R2 and R-2 group together to form an oxo group; R3 represents an H atom or C1-6 tar group, and finally is replaced by a c1-3, R4 and R5.H atom, a c1-7 tar is finally replaced, a c3-7 cyclopropyl or phenyl, a nafilo or un-c (x) R6; cyclopropyl compounds c3-7 and phenyl compounds are finally replaced, provided that at least one R4 or R5 group represents C (x) R6; X represents an atom or an S atom; R6 represents an alcox C1-6 group, A hydroxyl group or a-nr7r8 type; alcoxi C1-6 type is finally replaced by a phenyl; R7 and R8 represent an H atom, a possible substituted C1-6 tar, a c3-7 cyclopentadiene, a C1-6 oxygen or a phenyl, respectively; or R7 and R6, containing N atoms, form a cycle of aziridina and azeidina, PyrethrinPyridine or morphine; cyclopentanediol c3-7 and phenyl group were finally replaced; in basic state, acid salt or hydrate was added. Therapeutic application.