Acilaminotiazol Derivatives, their Preparation and their application in Therapeutics

摘要

Claim 1: compound that responds to the General formula (1) wherein, R1 represents an alkyl, or C1 - 6 eventually replaced by one to three a trifluoromethyl substituents selected from Halogen, Hydroxy, alkoxy, a C1 - 6 - 6, a tioalquilo C1 or phenyl, thiophene; or a Ci Cloalquilo C3 - 7, thiophene, benzothiophene, a pyridinyl,A furanilo or phenyl phenyl groups; these were eventually replaced by one to three substituents selected from a Halogen Atom, an alkyl alkoxy C1 C1 - 6, - 6, a Hydroxy, methylenedioxy, a phenoxy or Benzyloxy or a trifluoromethyl; R2 and R? ? 2 represent, independently, a H Atom, an atom of a Halogen, Hydroxy, alkoxy c1-3 alkyl, a C1 - 3A cycloalkyl Group C3 - 7, and - C (o) - alkyl - or 6 C1, R2 and R? ? 2 together form an oxo Group; R3 represents an H Atom, an alkyl C1 - 6 eventually substituted by Hydroxy, a cycloalkyl or an alkoxy C1 C1 - 6 - 3; R4 or R5 represents either a group Z and R4 or R5 represents indistinctlyA Group - C (X) R6 G represents a Single Bond or a - CH2 - Group; and represents a Single Bond or Atom, a, S, a group alquileno C1 - 4 or - N (W), the Group alquileno c1-4 is eventually replaced by a Hydroxy or alkoxy Group C1 - 3; W represents either a H Atom, or an alkyl C1 - 3 eventually replaced by a phenyl, phenyl or a; a and B representIndependently, a H atom of the Hydroxy Group, halogen, alkoxy alkyl, c1-3, c1-3, trifluoromethyl, trifluoromethoxy or - or - CHF2; provided that if is a link or a simple Atom or group and if z is of type as shown in formula (2), then a is different from H Atom; X represents an Atom or Atom or an alkoxy Group S; R6 represents a C1 - 6- nr7r8 Hydroxy or alkoxy Group; The C1 - 6 is eventually replaced by a phenyl; R (R7 and represent, independently, or an H Atom or an alkyl group C1 - C3 cycloalkyl eventually replaced by a 6 - 7, a cicloalquenilo C3 alkoxy - 7, a C1 - 3 a phenyl, morphology Or a pyridinyl quot; or a cycloalkyl Group C3 - 76 or phenyl alkoxy C1 - C3 - 7; these cycloalkyl groups and phenyl are eventually replaced by one or two groups selected from a Halogen Atom, an alkyl group, Hydroxy, alkoxy or C1 C1 - 3 - 3; and R7 and R8, with the N Atom form a cycle that leads, aziridine,. Pyrrolidine, PI, Paradine, morpholine or benzopiperidina Ground State; In addition, Salt with acidHydrate or solvate.