Compounds useful as inhibitors of voltage-gated ion channels regulated

摘要

1. Claim 1: a formula compound (1),Among them, each RN is an independent hydrogen or C1-4 non-material substitute, which is replaced by up to two substitutes selected from R1, R4 or R5; X1 is O, s or NRX; P is 0 or 1; Rx is h or R2; X2 is a c1-3 non-material substitute, which can be replaced by up to two substitutes selected from R1, R4 or R5 independently; Z from another set of formulas (2),T is an 8-14-membered aromatic or non-aromatic bicyclic or tricyclic ring, which has 0-5 heteroatoms selected from O, S, N, NH, S (O) or SO2; wherein the T ring is attached to the rest of the molecule through a carbon ring atom; wherein each of Z and T optionally comprises up to 4 substituents independently selected from R1, R2, R3, R4 or R5; R1 is oxo, = NN (R6) 2, = NN (R7) 2, = NN (R6R7),R6 or (CH2) n-Y; n is 0, 1 or 2; Y is halo, CN, NO2, CF3, OCF3, OH, SR6, S (O) R6, SO2R6, NH2, NHR6, N (R6) 2, NR6R8, COOH, COOR6 or OR6; or two R1 in adjacent ring atoms, taken together, form 1,2-methylenedioxy or 1,2-ethylenedioxy; R2 is aliphatic, wherein each R2 optionally comprises up to 2 substituents independently selected from R1, R4 or R5; R3 is a cycloaliphatic, aryl, heterocyclic or heteroaryl ring that optionally comprises up to 3 substituents independently selected from R1, R2, R4 or R5; R4 is OR5, OR6, OC (O) R6, OC (O) R5, OC (O) OR6, OC (O) OR5, OC (O) N (R6) 2, OC (O) N (R5) 2, OC (O) N (R6R5),OP (O) (OR6) 2 OP (O) (OR5) 2 OP (O) (OR6) (OR5)SR6, SR5, S (O) R6, S (O) R5, SO2R6, SO2R5, SO2N (R6) 2, SO2N (R5) 2, SO2NR5R6, SO3R6, SO3R5, C (O) R5, C (O) OR5, C (O) R6, C (O) OR6, C (O) N (R6) 2, C (O) N (R5) 2, C (O) N (R5R6),C (O) N (OR6) R6, C (O) N (OR5) R6, C (O) N (OR6) R5, C (O) N (OR5) R5, C (NOR6) R6, C (NOR6) R5, C (NOR5) R6, C (NOR5) R5, N (R6) 2, N (R5) 2, N (R5R6),NR5C (O) R5, NR6C (O) R6, NR6C (O) R5, NR6C (O) OR6, NR5C (O) OR6, NR6C (O) OR5, NR5C (O) OR5, NR6C (O) N (R6) 2, NR6C (O) NR5R6, NR6C (O) N (R5) 2, NR5C (O) N (R6) 2, NR5C (O) NR5R6, NR5C (O) N (R5) 2, NR6SO2R6, NR6SO2R5, NR5SO2R5, NR6SO2N (R6) 2, NR6SO2NR5R6, NR6SO2N (R5) 2, NR5SO2NR5R6, NR5SO2N (R5) 2, N (OR6) R6, N (OR6) R5, N (OR5) R5, N (OR5) R6, P (O) (OR6) N (R6) 2, P (O) (OR6) N (R5R6),P (O) (OR6) N (R5) 2 P (O) (OR5) N (R5R6)P (O) (OR5) N (R6) 2, P (O) (OR5) N (R5) 2, P (O) (OR6) 2, P (O) (OR5) 2 or P (O) (OR6 ) (OR5);R5 is a cyclopentene, arilo, isocyclic or isocyclic ring, which can optionally include up to three R1 substitutes; R6 is h or propylene, where R6 can optionally include one R7 substitute; R7 is a cyclopentene, arilo, isocyclic or isocyclic ring; and each R7 can optionally include up to two selected substitutes. Independent, from h, colon method o (CH2) N-Z ';Z se selecciona de halo CN NO2 CF3 OCF3 OH S-alif tico S (O) -alif tico SO2-alif tico NH2 N-alif tico N (alif tico) 2 N (alif tico) R8 COOH C (O) O (- R8 is an ammonia protection group, provided that: (1) when X2, x1, Q, and P are together - ch2-o,Then t is not the wreckage of an equation set (3)ii) when: X2, X1, q and p are together -CH2-S-,Then, t is not the wreckage of any formula group (4),B is hydrogen, methyl, n-propyl, isopropyl, allyl, benzene or phenyl.