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Combined preparation for simultaneous, separate, or sequential administration in cancer treatment, method for cancer treatment, use of at least one compound, and pharmaceutical composition

机译:在癌症治疗中同时,分开或依次给药的联合制剂,癌症治疗方法,至少一种化合物的用途和药物组合物

摘要

"COMBINED PREPARATION FOR SEPARATE, OR SEQUENTIAL ADMINISTRATION IN CANCER TREATMENT, METHOD FOR CANCER TREATMENT, USE OF AT LEAST ONE COMPOUND, AND PHARMACEUTICAL COMPOSITION". This invention relates to the combined preparation for simultaneous, separate or sequential administration in the treatment of cancer comprising two separate preparations: a preparation comprising, in combination with a pharmaceutically acceptable carrier or diluent, at least one compound of formula I: wherein each R ^ 1 ^ and R ^ 2 ^ independently represent a hydrogen atom, lower alkyl, or the like, and G represents pentosyl or similar, each X ^ 1 ^ and X ^ 2 ^ independently represent a hydrogen atom, a halogen atom, or the like or a pharmaceutically acceptable salt thereof; and a preparation, in combination with a pharmaceutically acceptable carrier or diluent, such as anti-tumor alkylating agents, anti-tumor antimetabolites, anti-tumor antibiotics, or plant-derived anti-tumor agents (a preparation comprising at least one compound of the Formula I or a pharmaceutically acceptable salt thereof may be combined with two or more other anti-tumor agents), and a method for treating cancer comprising administering these preparations in combination.
机译:“在癌症治疗中单独或依次管理的联合准备,癌症治疗方法,至少一种化合物的使用和药物组合物的组合”。本发明涉及在癌症的治疗中同时,分开或依次给药的组合制剂,其包括两种分开的制剂:一种制剂,所述制剂包含与药学上可接受的载体或稀释剂组合的至少一种式I的化合物:其中每个R ^ 1 ^和R ^ 2 ^独立地表示氢原子,低级烷基等,G表示戊糖基等,X ^ 1 ^和X ^ 2 ^各自独立地表示氢原子,卤素原子等或其药学上可接受的盐;以及与药学上可接受的载体或稀释剂(例如抗肿瘤烷化剂,抗肿瘤抗代谢物,抗肿瘤抗生素或植物来源的抗肿瘤剂)组合的制剂(包含至少一种所述化合物的制剂式I或其药学上可接受的盐可以与两种或更多种其他抗肿瘤剂组合,并且一种用于治疗癌症的方法包括组合施用这些制剂。

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