Oral composition of trimethobenzamide to treat and control nausea and / or vomiting.

摘要

"Oral composition of trimethobenzamide to treat and control nausea and / or vomiting". Oral trimethobenzamide compositions and methods for the treatment and control of nausea and / or vomiting are described in warm-blooded animals, especially humans including children. The oral trimethobenzamide compositions and methods of the present invention are at least as effective as an injectable formulation of 200 mg intramuscular (I.M.) trimethobenzamide HCl. In addition, an oral composition containing about 300 mg trimethobenzamide HCl is only approximately bioequivalent to an injectable formulation of 200 mg intramuscular (I.M.) trimethobenzamide HCl. When administered in a dose of about 100 mg. The pediatric oral trimethobenzamide compositions and methods of the present invention are believed to be at least as effective as an injectable formulation of 200 mg intramuscular (I.M.) trimethobenzamide HCl when administered at a dose of about 100 mg. In addition, a pediatric oral composition containing about 120 mg trimethobenzamide HCl is believed to be only approximately bioequivalent to an injectable formulation of intramuscular (I.M.) trimethobenzamide HCl 200 mg when administered at a dose of about 100 mg.