Solid dosage formulation, controlled release tablet, method of manufacturing a controlled release medication, pharmaceutical composition and use of a composition

摘要

"SOLID DOSAGE FORMULATION, COMPRESSED FOR CONTROLLED RELEASE, METHOD OF MANUFACTURING CONTROLLED RELEASE MEDICATION, PHARMACEUTICAL COMPOSITION AND USE OF A COMPOSITION". Solid dosage formulation having a core with a pharmacological agent dispersed in a first controlled release matrix from which the agent release is relatively slow; and a coating formed on the core and having the agent dispersed in a second controlled release matrix from which release of the agent is relatively rapid. The first matrix may be a cross-linked high amylose starch and the second matrix may be a mixture of polyvinyl acetate and polyvinyl pyrrolidone.