Positive allosteric modulators of AMPA receptors naftotiazina (paarm)

摘要

1.- Compounds of the general formula (I) in which R1 means a radical chosen from the group consisting of hydrogen, a C1-C6 alkyl group optionally substituted with one or more halogen atoms, -SO2H, -SO2- -C1-C6 alkyl , -SO-C1-C6-alkyl, -CO-C1-C6-alkyl, -O, phenyl-C1-C4-alkyl, -C1-C4-alkyl-NR6R7 and -C1-C4-alkyl-C1-C4-alkyl, and cycloalkyl C3-C6, R2, R3, the same or different, mean a radical chosen from the group consisting of hydrogen, a C1-C6 alkyl group optionally substituted with one or more halogen, halogen, -NO2, -SO2H, -SO2-alkyl atoms C1-C6, -SO-C1-C6-alkyl, -CO-C1-C6-alkyl, -OH, -O-C1-C6-alkyl, -S-C1-C6-alkyl,C 1 -C 4 -alkyl-NR6R7 and -C 1 -C 4 -alkyl-O-C 1 -C 4 -alkyl, and C3-C6-cycloalkyl, oR1 and R2, together, mean a C4-C6, R6, R7 alkylene bridge, the same or different, mean hydrogen, C1-C4 alkyl or -CO-C1-C4 alkyl, R4, the same or different, means a radical chosen from the group consisting of a C1-C6 alkyl group optionally substituted with one or more halogen atoms, phenyl-C1- alkyl C4, halogen, -CN, -NO2, -SO2H, -SO3H, -SO2-C1-C6-alkyl, -SO-C1-C6-alkyl, -SO2-NR6R7, -COOH, -CO-C1-C6-alkyl, TO- CO-C1-C4-alkyl, -CO-O-C1-C4-alkyl, -O-CO-O-C1-C4-alkyl, -CO-NR6R7, -OH, -O-C1-C6-alkyl, -S-C1-alkyl -C6, -NR6R7 and an aryl radical, optionally substituted,once or several times, with halogen atoms, -NO2, -SO2H or C1-C4 alkyl, R5, the same or different, means a radical chosen from the group consisting of a C1-C6 alkyl group optionally substituted with one or more atoms of halogen, phenyl-C1-C4-alkyl, halogen, -CN, -NO2, -SO2H, -SO3H, -SO2-C1-C6-alkyl, -SO-C1-C6-alkyl, -SO2-NR6R7, -COOH, -CO- C1-C6-alkyl, -O-CO-C1-C4-alkyl, -CO-O-C1-C4-alkyl, -O-CO-O-C1-C4-alkyl, -CO-NR6R7, -OH, -O-C1-alkyl -C6, -S-C1-C6-alkyl, -NR6R7 and an aryl radical, optionally substituted, once or several times, with halogen atoms, -NO2, -SO2H or C1-C4-alkyl, and n, m, the same or different , mean 0, 1,2 or 3, provided that [1, 8-de] - 2, 3-dihydro-1, 1-sulfur dioxide-1, 2-tiazina is not included, and may take the form of its corresponding isomer and symmetric isomer, as well as its salts with safety characteristics.