New positive allosteric Modulator of AMPA receptors (paarm), processes for their Preparation and their use as medicaments

摘要

It refers to the Western Sahara modulator of new n-propane receptor in general formula (1), i.e., a refers to a sulfur atom, an oxygen atom, NH or n-tar C1-4; R1 refers to a radical modulator selected from group D and hydrogen group, In a group of C1-6 tar, one or more halogenated atoms and C1-6, C1-6, so-so2-tar, C1-6, C1-6, CO tar, or phenyl C1-4, c1-4-nr7r8 yalquil c1-4-o-c1-4, c1-4-tar or C3-6, R2, R9 or other substances are eventually replaced. They're radicals from the hydrogen groupThe C1-6 tar of deun formation is finally replaced by one or more halogenated atoms and halogenated carbon, NO2, so2h, so2-al quilo C1-6, so-c1-6, CO tar, C1-6, oh, or C1-6, c1-4-nr7-6, C1-4 - or C1-6 tar, or c1-o tar of c1-3-6; or un-r2 refers to a C1-6 bridge; R7, R8 are equivalent or different, signi can ignore C1-4 hydrogen or hydrocarbon; R3, R4, R5, R6 are equivalent or different, which means that in the group composed of hydrogen, a group of C1-6 tar (eventually replaced by one or more halogenated atoms) and a group of C1-4, halocarbon-4, C2, NO2, so2h, SO3H radionuclides,-SO2-C1-6 alkyl, -SO-C1-6 alkyl, -SO2-NR7R8, -COOH, -CO-C1-6 alkyl, -O-CO-C1-4 alkyl, -CO-O-C1-4 alkyl , -CO-NR7R8-C1-4 alkyl, -OH, -O-C1-6 alkyl, -S-C1-6 alkyl, -NR7R8 and an aryl radical optionally substituted once or multiple times with halogen atoms, -NO2, -SO2H or C1-4alkyl, possibly in the form of its different enantiomers and diastereoisomers, as well as their pharmacologically-acceptable salts. A procedures for its preparation as well as its use as medicines. Useful in dementia, neurodegenerative or psychotic diseases.