PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF DAMAGES OF TISSUES CAUSED BY INSUFFICIENCY OF ARTERIAL BLOOD

摘要

The present invention relates to medicine and especially to a pharmaceutical combination of epidermal growth factor (EGF) and hexapeptide enhancing secretion of growth hormone (GHRP), which is suitable for preventing tissue damage caused by suppressing blood flow, as well as enhancing tissue regeneration after ischemic damage. The above-mentioned combination can be used as a single pharmaceutical composition. Alternatively, the patient may also receive both EGF and GHRP separately, but as part of a single therapeutic regimen, to enhance cell survival when the organs lose blood flow for a critical period of time. This combination reduces the formation of reactive oxygen species (ROS) and the associated cytotoxicity. It is suitable for promoting cell survival when tissues or organs are exposed to prolonged periods of ischemia. This combination can be used as a prophylactic agent in patients prone to multiple organ failure (MOF), such as burn patients, patients with multiple injuries, newborns in a state of hypoxia, patients with acute respiratory distress syndrome and patients with necrotizing enterocolitis. Report on the international The search was published 2002.11.14.