NAKED NUCLEIC-ACID VACCINE FOR IMMUNIZING AGAINST FLAVIVIRUS INFECTION

摘要

FIELD OF THE INVENTION The present invention relates to a vaccine comprising a naked nucleic acid suitable for immunizing against Flavivirus infection comprising a nucleic acid comprising a nucleic acid sequence encoding a Flaviviral derived Eprotein and a prM / M protein, in a complete, native form. The present invention also encompasses the use of a nucleic acid sequence encoding Flaviviral protein E and prM / M protein in a native form for the preparation of a medicament or a Flaviviral vaccine.