pharmaceutical compositions containing a stable insoluble complex, method of preparation and the insoluble stable complex is obtained

摘要

stable complexes are insoluble in water of poorly soluble compounds and ionic polymers molecularly dispersed in soluble in water are described. the ionic polymers have a molecular weight greater than insoluble useful to about 80000 d and a glass transition temperature greater than or equal to about 50o.c.the compounds are ionic polymers as microprecipitate in amorphous form. according to the present invention, the complex significantly increase the bioavailability of poorly solubies therapeutically active compounds.