PHARMACEUTICAL COMPOSITION, METHODS FOR ITS PREPARING, STABLE WATER-INSOLUBLE COMPLEXES, METHOD FOR CONVERSION OF THERAPEUTICALLY ACTIVE COMPOUND AND THERAPEUTICALLY ACTIVE COMPOUND

摘要

FIELD: pharmaceutical technology and compositions, pharmacy.;SUBSTANCE: invention relates to pharmaceutical compositions comprising stable water-insoluble complex consisting of the stable amorphous therapeutically active compound dispersed in water-insoluble ionic polymer at the molecular level. Useful insoluble ionic polymers have molecular mass above about 80 000 Da and vitrification point about 50^oC or above. Compounds are subjected for microprecipitation in amorphous form on ionic polymers. Proposed complexes enhance biological availability of slightly soluble therapeutically active compounds significantly.;EFFECT: improved preparing method, enhanced and valuable properties of composition.;41 cl, 7 dwg, 2 tbl, 16 ex