Preparation of salt 5 - (R) - 2 - (5,6-diethyl-ndan-2-ethyl) - 1-hydroxy-ethyl - 8-hydroxy - (1H) - quinoline-2-ona

摘要

It refers to the preparation procedure of salt 5 [(R) - 2 - (5). 6-dietil-indan-2-ilamino-1-hydroxi-ethi] - 8-hydroxi - (1H) - quinolin-2-ona, including: (a) oxi-5 - (R) - oxinal - (1H) - quinolin-2-ona 8 is replaced by 2-amine - (5-6-dietil) to form a reaction mixture, which contains a protective group of compounds; (b) When the solvent forms the corresponding salt, the mixed reaction is treated in the acid; (c) the salt is separated and crystallized;(d) In the presence of solvent, the salt protection group is removed to obtain a compound, and finally in the presence of solvent, when 5 - [(R) - 2 - (5,6-dietil-indan-2-ilamin o) - 1-hydroxi-ethi] - 8-hydroxi - (1H) - quinolin-2-one de formula VII, X is anion, it is treated in acid solution. These compounds are adrenaline selective agonists and can be used in the treatment of asthma and EPOC.