process for the preparation of useful 5 - (r) -2- (5,6-diethyl-indan-2-ylain) -1-hydroxy-ethyl -8-hydroxy (1h) -quinolin-2-one salt as an adrenoceptor agonist

摘要

"PROCESS FOR THE PREPARATION OF 5- ¢ (R) -2- (5,6-DIETHYL-INDAN-2-YLAMINO) -1-HYDROXY-ETHYL-8-HYDROXY (1H) QUINOLIN-2-ONA SALT , USEFUL AS AN ADRENOCEPTOR AGONIST ". The present invention relates to a process for the preparation of 5- (R) -2- (5,6-diethyl-indan-2-ylamino) -1-hydroxyethyl-8-hydroxy- ( 1H) -quinolin n-2-one. The process involves the formation of an oxy (1H) quinolin-2-one 5- (R) -2- (5,6-diethyl-indan-2-ylamino) -1-hydroxy-ethyl-1-oxide salt. Acid-8-Substituted and Acid-Salt Coverage to a 5- (R) -2- (5,6-diethyl-indan-2-ylamino) -1-hydroxy-ethyl-8-hydroxy- (1H) -quinoline salt -2-one without separation of the 5 ¢ (R) -2- (5,6-diethyl-indan-2-ylamino) -1-hydroxy-ethyl-8-hydroxy- (1H) -quinolin-2 free base -one.