An improved procedure for the preparation of 2 - (etoximetyl) - tropino derivatives

摘要

It refers to a process for preparing 2 - (etoximetyl) derivatives. In one formula, R1 is h, C1-C6 tar; R2 is halide, trifluoroide and cyanogen, and its characteristic is that 2 - (hydroxy) derivatives are secondary preparation, When it reacts with ethyl bromide, phase transfer catalysts such as potassium hydrogen, tetrabromodiphenyl ether and diluents such as toluene are used,DICHLOROMETHANE OR 1,2-DIMETOXYETHANE AND THEN IT IS TREATED WITH AN ACID. THE PROCEDURE IS CARRIED OUT AT A RANGE OF -10 ° C TO 90 ° C. THE ETHYL BROMIDE IS ADDED DOSAGEALLY IN THE SPACE OF 5 TO 180 MINUTES AND THE REACTION MIXTURE CONTINUES TO SHAKE FOR 30 TO 180 MINUTES. THE PROCEDURE IS CHARACTERIZED BECAUSE AFTER THE REACTION WITH ETHYL BROMIDE IS COMPLETED, WATER IS ADDED TO THE REACTION MIXTURE, THE PHASES ARE SEPARATED, THE ORGANIC PHASE IS WASHED WITH WATER, IT IS CONCENTRATED WITH REDUCED PRESSURE AND THE RESIDUE IS TREATED WITHOUT PURIFICATION THE CORRESPONDING ACID