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Aldosterone receptor antagonist and alpha-adrenergic modulating agent combination therapy for the prevention or treatment of pathogenic conditions.
Aldosterone receptor antagonist and alpha-adrenergic modulating agent combination therapy for the prevention or treatment of pathogenic conditions.
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机译:醛固酮受体拮抗剂和α-肾上腺素调节剂联合治疗可预防或治疗致病性疾病。
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摘要
A combination therapy comprising a therapeutically-effective amount of an aldosterone receptor antagonist and a therapeutically-effective amount of an alpha-adrenergic modulating agent is described for treatment of circulatory disorders, including cardiovascular disorders such as hypertension, congestive heart failure, cirrhosis and ascites. Preferred alpha-adrenergic modulating agents are those compounds having high potency and bioavailability. Preferred aldosterone receptor antagonists are 20-spiroxane steroidal compounds characterized by the presence of a 9alpha,11alpha-substituted epoxy moiety. A preferred combination therapy includes an alpha-1-adrenergic antagonist or an alpha-2-adrenergic agonist and the aldosterone receptor antagonist epoxymexrenone.
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