VIRAL AND NON-VIRAL RECOMBINING VECTORS CONTAINING THE HUMAN GENE OF THE PLASMINOGEN ACTIVATOR AND ITS USE IN THE TREATMENT OF VARIOUS TYPES OF HEPATIC, RENAL, PULMONARY, PANCREATIC AND CARDIAC AND HYDRAPHIC.

摘要

The present invention describes recombinant adenoviral vectors in which the El and / or E3 reading frames have been deleted, which contain a therapeutic gene that is selected from the human urokinase derived plasminogen activator (huPA) gene, the gene of the truncated TGF-beta type II receptor and the hepatocyte growth factor (HGF) gene among others. The invention also describes methods of preparing the vectors, compositions made with the vectors and their use in gene therapy for cirrhosis and other types of fibrosis.