THE COMBINATION OF GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR-1 ENHANCES GROWTH

摘要

A method is disclosed for enhancing growth of a mammal by administration of acombination of effective amounts ofIGF-I and GH so as to enhance the growth of the mammal over the enhancement ingrowth achieved using either IGF-I or GHalone in an amount equal to that used for either IGF-I or GH, respectively, inthe combination. Preferably, the mammal is achild, the IGF-I is native-sequence, mature human IGF-I or human brain IGF-I,and the GH is native-sequence, mature humanGH with or without a terminal methionine. In another preferred embodiment, themammal is a non-human animal of economicimportance such as a cow or pig.