METHOD FOR THE TREATMENT OF THE COMPLICATIONS AND PATHOLOGY OF DIABETES

摘要

The present invention provides a method for the treatment of the complicationsand pathology of diabetes. The methodinvolves the administration to a diabetic subject of a composition comprisinga compound selected from the group consisting of(.beta.-Ala-His)n, (Lys-His)n, a compound of the formula R1-X-R2,pharmaceutically acceptable salts thereof and combinationsthereof; and a pharmaceutically acceptable carrier, in which n is 2-5, R1 isone or two naturally occurring amino acids,optionally alpha-amino acetylated with alkyl or aralkyl of 1 to 12 carbonatoms, preferably 2 to 6 carbon atoms, R2 is 1 or 2naturally occurring amino acids, optionally alpha-carboxyl esterified oramidated with alkyl or aralkyl of 1 to 12 carbonatoms, preferably 2 to 6 carbon atoms and X is R3-L or D-His (R4)-R5 where R3is void or .omega.-aminoacyl with 1 to 12 carbonatoms, preferably 2 to 6 carbon atoms, R4 is void or imidazole modificationwith alkyl-sulphydryl, hydroxyl, halogen and/oramino groups; and R5 is void or carbonyl (alkyl) amides with 1 to 12 carbonatoms, preferably 2 to 6 carbon atoms.Preferably, the compound is carnosine.