NOVEL MUTATED VIRUSES, ANTI-VIRAL COMPOUNDS AND NOVEL METHODS OF MAKING VACCINES

摘要

The present invention provides a composition of matter, comprising a non-infectious, mutated virus suitable for use in preparinga vaccine. A plasmid adapted for expression in a recombinant cell comprising DNA encoding non-infectious mutated virus protein andregulatory elements necessary for expression of said DNA in the cell. Also provided are methods of inhibiting the spread of infection of avirus comprising the step of contacting said virus with a compound that inhibits thiol-reductase/protein disulfide isomerase activity in saidvirus.