CONTROLLED RELEASE BY EXTRUSION OF SOLID AMORPHOUS DISPERSIONS OF DRUGS

摘要

Controlled release dosage forms for lowsolubility drugs are disclosed wherein an amorphous soliddispersion of the drug is coated with a non-dissolvingand non-eroding coating that controls the influx of waterto the core so as to cause extrusion of a portion of thecore, as well as a method of treating a disease ordisorder comprising administering such dosage form to aperson.