COMPOSITIONS OF A BENZENESULFONAMIDE OR METHYLSULFONYLBENZENE CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A CHOLINERGIC AGENT FOR THE TREATMENT OF REDUCED BLOOD FLOW OR TRAUMA TO THECENTRAL NERVOUS SYSTEM

摘要

The present invention provides methods and compositions for the treatment ofcentral nervous system damage in a subject. More particularly, the inventionprovides a combination therapy for the treatment of a central nervous systemischemic condition or a central nervous system traumatic injury comprising theadministration to a subject of a cholinergic agent in combination with abenzenesulfonamide or methylsulfonylbenzene cyclooxygenase-2 selectiveinhibitor.