Western States Medical Monographs. Selective Serotonin Reuptake Inhibitor Use as a Risk Factor for Blood Transfusion in Trauma Management.

摘要

This study examines the use of Selective Serotonin Reuptake Inhibitors (SSRIs) as a risk factor for blood transfusion utilization in Emergency Department trauma activation patients. A retrospective cohort control study at Arrowhead Regional Medical Center was conducted in the Emergency Department reviewing computer profiles for adult patients with trauma activation status from January 2012 to December 2014. Patients using SSRIs were compared to all trauma activation patients that met inclusion and exclusion criteria using a likelihood ratio analysis. After the exclusion of 710 patients, as consistent with study criteria, 40 trauma activation patients using SSRIs were compared with 1126 trauma activation patients not taking SSRIs. There was no demonstrated evidence of an association or significant difference in the likelihood ratio between SSRI use and blood transfusions. For Hispanics, four of 17 (23.5%) SSRI users received a blood transfusion while 63 of 552 (11.4%) non-SSRI users received a blood transfusion. A possible association (P-Value 0.127) and difference in the likelihood ratio (P-Value 0.169) was demonstrated. Also, for patients above 50 years old four of ten (40%) SSRI users received a blood transfusion while 36 of 182 (19.8%) non-SSRI users received a blood transfusion. A possible association (P-Value 0.125) and difference in likelihood ratio (P-Value 0.156) was demonstrated. No statistically significant association was shown between SSRI users and blood transfusion utilization. An association may exist between SSRI usage and blood transfusions for Hispanic trauma activation patients and trauma activation patients greater than 50 years of age.