COMPOSITION FOR THE PREVENTION/TREATMENT OF HBV INFECTIONS AND HBV-MEDIATED DISEASES

摘要

The invention relates to compositions containing at least two hepatitis Bvirus surface antigens (HBsAg's), fragments thereof and/or nucleic acids thatcode for said antigens, the HBsAg's in the HBV genotype differing in the Sregion and/or pre-S1 region and the composition containing no HBV core antigen(HBcAg) or nucleic acid that codes for said antigen. The invention alsorelates to pharmaceutical compositions, in particular vaccines containing saidcompositions, for the prophylaxis/treatment of an HBV infection or a diseasemediated by HBV. The invention further relates to a method for producing apatient-specific medicament for the therapeutic treatment of hepatitis B.