ANTI-VASCULAR AND ANTI-PROLIFERATION METHODS, THERAPIES, AND COMBINATIONS EMPLOYING SPECIFIC TYROSINE KINASE INHIBITORS

摘要

This invention is directed to potent inhibitors of protein tyrosine kinasealone or in synergistic combination with antiangiogenic or chemotherapeuticagents for the abrogation of mature vasculature within chemotherapeuticrefractory tumors, pharmaceutical compositions comprising these compounds, andto the use of these compounds for treating a patient suffering from or subjectto disorders/conditions involving cell proliferation, and particularlytreatment of brain cancer, ovarian cancer, pancreatic cancer prostate cancer,and human leukemias, such as CML, AML or ALL.