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Anti-vascular and anti-proliferation methods, therapies, and combinations employing specific tyrosine kinase inhibitors
Anti-vascular and anti-proliferation methods, therapies, and combinations employing specific tyrosine kinase inhibitors
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机译:使用特定酪氨酸激酶抑制剂的抗血管和抗增殖方法,疗法和组合
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摘要
This invention is directed to potent inhibitors of protein tyrosine kinase alone or in synergistic combination with antiangiogenic or chemotherapeutic agents for the abrogation of mature vasculature within chemotherapeutic refractory tumors, pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cell proliferation, and particularly treatment of brain cancer, ovarian cancer, pancreatic cancer prostate cancer, and human leukemias, such as CML, AML or ALL.
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