METHOD OF DETECTING CONFORMATIONAL CHANGE OF AN AMYLOID PROTEIN, A METHOD OF SEARCHING A SUBSTANCE HAVING AN ACTIVITY THAT AFFECTS TO CONFORMATIONAL CHANGE OF AN AMYLOID PROTEIN, AND A METHOD OF SEARCHING A THERAPEUTIC OR DIAGNOSTIC AGENT FOR AMYLOID-RELATED DISEASES

摘要

As the results of studies aiming at providing a means for real-time detectionand assay of the amyloid protein aggregation process as a change in tensionand/or elasticity with the use of a power sensor, a method of detecting anamyloid structural change in a protein with the use of a mechanochemicalsensor is provided. Moreover, a method of searching for a substance having anactivity of affecting an amyloid structural change by using the above method,and a method of screening a remedy or a diagnostic for an amyloid-relateddisease are provided. These methods seemingly contribute to the acquisition ofa novel remedy/diagnostic for an amyloid disease.