METHOD OF DETECTING AMYLOID STRUCTURAL CHANGE IN PROTEIN, METHOD OF SEARCHING FOR SUBSTANCE HAVING ACTIVITY OF AFFECTING AMYLOID STRUCTURAL CHANGE AND METHOD OF SEARCHING FOR REMEDY OR DIAGNOSTIC FOR AMYLOID-RELATED DISEASE

摘要

The inventors investigated to provide a means for real-time detection and measurement on the process of the amyloid protein aggregation as change(s) in tension and/or elasticity using a force sensor. The present invention provided a method of detecting an amyloidgenic conformational change of a protein using a mechanochemical sensor. The present invention further provided a method of searching a substance having an activity that affects to an amyloidgenic conformational change using said detecting method, as well as a method of searching a therapeutic or diagnostic agent for amyloid-related diseases. The method of the present invention is assumed to contribute to obtain a novel therapeutic or diagnostic agent for amyloid diseases.